منابع مشابه
Growth hormone, inflammation and aging
Mutant animals characterized by extended longevity provide valuable tools to study the mechanisms of aging. Growth hormone and insulin-like growth factor-1 (IGF-1) constitute one of the well-established pathways involved in the regulation of aging and lifespan. Ames and Snell dwarf mice characterized by GH deficiency as well as growth hormone receptor/growth hormone binding protein knockout (GH...
متن کاملGrowth hormone and aging: A challenging controversy
Although advanced age or symptoms of aging are not among approved indications for growth hormone (GH) therapy, recombinant human GH (rhGH) and various GH-related products are aggressively promoted as anti-aging therapies. Well-controlled studies of the effects of rhGH treatment in endocrinologically normal elderly subjects report some improvements in body composition and a number of undesirable...
متن کاملGrowth Hormone Replacement for Normal Aging
The purpose of this paper is to discuss whether or not growth hormone replacement therapy (GHRT) for the treatment of somatopause of normal aging is safe and effective. In order to determine this it is important to learn about GH, the benefits of GHRT, and its side-effects. We also need to discuss whether or not pathological GH deficiency is the same as GH deficiency caused by “normal aging.” T...
متن کاملPleiotropic effects of growth hormone signaling in aging.
Growth hormone (GH) affects somatic growth, sexual maturation, body composition and metabolism, as well as aging and longevity. Mice lacking GH or GH receptor outlive their normal siblings and exhibit symptoms of delayed aging associated with improved insulin signaling and increased stress resistance. Beneficial effects of eliminating the actions of GH are counterintuitive but conform to the co...
متن کاملJuvenile Hormone Regulates Extreme Mandible Growth in Male Stag Beetles
The morphological diversity of insects is one of the most striking phenomena in biology. Evolutionary modifications to the relative sizes of body parts, including the evolution of traits with exaggerated proportions, are responsible for a vast range of body forms. Remarkable examples of an insect trait with exaggerated proportions are the mandibular weapons of stag beetles. Male stag beetles po...
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ژورنال
عنوان ژورنال: Best Practice & Research Clinical Endocrinology & Metabolism
سال: 2013
ISSN: 1521-690X
DOI: 10.1016/j.beem.2013.05.003